Daufuskie Island can only be accessed by ferry. Please see information on Ferry Transportation for detailed information and the ferry schedule. Getting to either on of the two embarketion center on Hilton Head Island is fairly simple.

From I-95 To Broad Creek Marina, Calibogue Cruises
(843-342-8687):
Take Exit 8 from I-95 and head East on Highway 278. Stay on Highway 278 for about 20 miles or 30 plus minutes depending upon traffic and cross over the only bridge to Hilton Head Island. (Please note the Saturday traffic in the summer can substantially lengthen the travel time.) Proceed to traffic light at 278 and Spanish Wells Road. Take a right at the light onto Spanish Wells Road and continue for 2 miles until stop sign. Take a left onto Marshland Road for 1 mile then take a right on Simmons Road to Broad Creek Marina entrance on right.  (See “Ferry Transportation”)

Location 18 Simmons Road, Hilton Head Island, SC 29926

From the Savannah/Hilton Head International Airport:
Depart the Savannah, Georgia airport when in a few minutes you will enter I-95 going NORTH. Follow I-95 North crossing into South Carolina. Continue until you reach Exit 8. Turn right (East) at the end of Exit 8 onto Highway 278 then follow the directions above from I-95